AF64394 游离
WBYNZQXAAWPAGR-UHFFFAOYSA-N
CAS: 1637300-25-4
Molecular Formula: C21H20ClN5O
AF64394 游离 - Names and Identifiers
AF64394 游离 - Physico-chemical Properties
| Molecular Formula | C21H20ClN5O |
| Molar Mass | 393.87 |
| Density | 1.31±0.1 g/cm3(Predicted) |
| Solubility | DMSO : ≥ 125 mg/mL (317.36 mM);H2O : < 0.1 mg/mL (insoluble) |
| pKa | 2.37±0.40(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | AF64394 is a GPR3 inverse agonist, with a pIC 50 of 7.3. AF34394 and related compounds are only of modest potency and are relatively lipophilic (e.g., AF34394 clogP=5.2, LLE=2.1, and 14b clog P=3.1 and LLE=3.2) the series shows promising SAR and represents an excellent start point for further optimization. |
AF64394 游离 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.539 ml | 12.695 ml | 25.389 ml |
| 5 mM | 0.508 ml | 2.539 ml | 5.078 ml |
| 10 mM | 0.254 ml | 1.269 ml | 2.539 ml |
| 5 mM | 0.051 ml | 0.254 ml | 0.508 ml |
Last Update：2024-01-02 23:10:35
AF64394 游离 - Reference Information
| biological activity | AF64394 is an inverse agonist of GPR3 with a pIC50 value of 7.3. |
| Target | pIC50: 7.3 (GPR3). |
Last Update：2024-04-09 22:09:11
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Mobile: 18021002903
QQ: 3008007409
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